How does diabetes negatively cause cognition problems? New research shows a strong link between diabetes and Alzheimer’s disease. It explains that diabetes can cause many potentially negative effects on cognition, metabolism, and mood and all of these are common aspects of Alzheimer’s disease.
Previous studies have shown that people with type 2 diabetes are more likely to get Alzheimer’s disease. However, the real structure behind this association has not been cleared yet. In a new study on mouse models, the researchers studied the impact of impairing insulin signaling in the brain and insulin-like growth factor (IGF1) receptors.
The research, conducted by experts from the Joslin Diabetes Center, affiliated with Harvard Medical School in Boston, MA, was published in the Proceedings of the National Academy of Sciences.
The findings show that blocking these receptors damaged both learning and memory. Senior author C. Ronald Kahn says that Alzheimer’s is not a normal part of aging and there is no cure for the condition.
However, there are treatments available that can reduce its development and may improve the quality of life of a person. Kahn is a chief academic officer at Joslin and the Mary K. Iacocca Professor of Medicine at Harvard Medical School. The researchers note that this is the firsts study which indicates a link between disrupted pathways and Alzheimer’s disease.
“With diabetes and obesity, there is resistance in these pathways and, therefore, we think that this could be an important factor as to why people with Alzheimer’s disease and diabetes have a faster-accelerated course or have more Alzheimer’s disease,” said Senior author C. Ronald Kahn.
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